Produktbeschreibung
DNA was prepared from cell line WM983A. WM983A is a VGP human malignant metastatic melanoma cell line that features the V600E (Val600Glu) mutation at codon 600 in the BRAF gene. This mutation causes constitutively active kinase activity and activation of MEK and ERK signaling pathway. This cell line is wild type for PTEN, N-RAS, c-KIT, and CDK4. This cell line was derived from the same patient as the cell lines WM983B, WM983B BR and WM983C.WM983A cells produce xenograft tumors when injected into immunocompromised mice.
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