| Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using rat Nb2-11 lymphoma cells is less than 0.1ng/ml, corresponding to a specific activity of > 1.0x10e7 IU/mg. Sequence: FPTIPLSRLF DNAMLRAHRL HQLAFDTYQE FEEAYIPKEQ KYSFLQNPQT SLCFSESIPT PSNREETQQK SNLELLRISL LLIQSWLEPV QFLRSVFANS LVYGASDSNV YDLLKDLEEG IQTLMGRLED GSPRTGQIFK QTYSKFDTNS HNDDALLKNY GLLYCFRKDM DKVETFLRIV QCRSVEGSCG F Molecular Weight: 22kD PubMed ID: 386281, 377496, 6269091, 7169009, 2744760, 18473352, 16625196, 10931946, 15489334, 3912261, 5810834, 5144027, 4675454, 5279046, 5279528, 7462247, 7356479, 7028740, 8364549, 14997482, 10e393484, 16807684, 3447173, 1549776, 7984244, 8943276, 8552145, 9152628, 9276733, 10e391209, 11502836, 12655557, 15001589, 15713716, 17519310 Gene Name: GH1 Swiss Prot: P01241 Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20C. Reconstituted product is stable for 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. |
