Neuropeptide Y (NPY), a neuropeptide colocalized and abundantly released with the neurotransmitter norepinephrine in nervous system, synthesized by postnatal olfactory epithelium of sustentacular cells. It promotes the proliferation of postnatal neuronal precursor cells and exhibits a diverse range of important physiologic activities, including effects on psychomotor activity, food intake, regulation of central endocrine secretion, and potent vasoactive effects on the cardiovascular system. NPY a 97aa peptide in mouse, human (chr 7p15.1) and 98aa in rat has a mol. wt of 11kD. NPY shows sequence homology to Peptide YY (PYY) and over 50% homology in amino acid and nucleotide sequence to Pancreatic Polypeptide (PNP or PPY), all of these homologous peptides has a 36aa mature peptide characterized by a hairpin loop. PPY: It was the first identified product (95aa in full) of the dominating endocrine cell type of the duodenal pancreas, this hormone of 36aa mature peptide (human, chr 17q12-q21) seems to be involved in the regulation of exocrine pancreatic secretion and biliary tract motility. Inhibits the secretion of enzymes and bicarbonates from exocrine pancreas. Source: 14aa peptide from Mouse PPY1 (1) Location: Mature Peptide region Species Sequence Homology: Bovine-78%. Applications: Suitable for use in ELISA as a control peptide for P3000-06. Other applications not tested. Recommended Dilution: ELISA: Coat ELISA plates at 1ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Reinheit:
Purified
Formulierung:
Supplied as a lyophilized powder from PBS, 0.05% sodium azide.
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