Inflammasomes are multiprotein complexes, responsible for the activation of inflammatory responses. Inflammasome activation is initiated by various cytosolic pattern recognition receptors (PRRs), including the NLR family of receptors. The NLRP3 inflammasome assembles NLRP3, ASC, and pro-caspase-1, leading to the activation of caspase-1, the cleavage and secretion of interleukin 1β (IL-1β) and interleukin 18 (IL-18) in response to diverse stimuli. NEK7 is the smallest of the eleven (NEK1-...

Immune checkpoints are regulators of the immune system which prevent the immune system from attacking self-antigens indiscriminately.  While this is critical to preventing auto-immune disease it also causes the immune system to be ineffective in eradicating or suppressing cancer. Tumor cells exploit certain immune-checkpoint pathways as a major mechanism of immune resistance, particularly against T cells that are specific for tumor antigens. Because many of these immune checkpoints are initiated by ligand-receptor interactions, they can...

PathPlus™ antibodies from LifeSpan  Biosciences (LSBio) represent the highest quality reagents available for research pathology applications. These reagents were selected from among thousands of antibodies, tested in immunohistochemistry on formalin...

DNA is a macromolecule capable of adopting many different conformations. In addition to the canonical Watson-Crick B-DNA, at least another 10 different conformations have been identified, with Z-DNA in particular attracting more and more attention (Wang et al., 2007). Z-DNA...

With AlphaThera's oYo-Link® technology, antibody conjugation is simple, fast, and site-specific - with as little as 1 µg of antibody per reaction needed.The entire procedure requires just two-steps and less than than 30 second...

Monovalent Fab fragments of affinity-purified secondary antibodies are offered to block endogenous immunoglobulins, to cover immunoglobulins when double labeling primary antibodies from the same host species, or to Fab-label primary antibodies prior to incubation with the experimental sample. ...

Bio X Cell offers InVivoPlus™ versions of our most popular InVivoMAb™ products. The InVivoPlus™ versions of their products are structurally and functionally identical to the InVivoMAb&trad...

We invite you to join our partner Sino Biological's upcoming scientific webinar on current methods of recombinant antibody production.     Recombinant Antibody Production: Current Methods and a Novel Antibody Generation Platform Antibodies are bio-macromolecules that bind to the...

It was a great pleasure for us to welcome you in such large numbers at the BIOZOL booth at this year's Analytica in Munich. Thank you to all our visitors for the good conversations and impulses! Especially our donation wheel was again very popular: Here our visitors could spin amounts between 1 and 18 Euro, and then choose one of three research organizations to which BIOZOL will donate these amounts.&n...

We are excited to announce the introduction of SouthernBiotech's new monoclonal and polyclonal secondary antibodies specific to llama IgG1, IgG2/IgG3, IgM, and IgG(H+L). SouthernBiotech anti-llama secondary antibodies ar...