OAS1 Antibody - middle region
Catalog Number:
ASB-ARP51359_P050
- Images (9)
| Article Name: | OAS1 Antibody - middle region |
| Biozol Catalog Number: | ASB-ARP51359_P050 |
| Supplier Catalog Number: | ARP51359_P050 |
| Alternative Catalog Number: | ASB-ARP51359_P050-25UL,ASB-ARP51359_P050-100UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | IHC, WB |
| Species Reactivity: | Bovine, Canine, Equine, Guinea pig, Human, Mouse, Porcine, Rabbit, Rat |
| Immunogen: | The immunogen is a synthetic peptide directed towards the middle region of human OAS1 |
| Alternative Names: | OIAS, IFI-4, OIASI, E18/E16 |
| This protein is a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2-specific nucleotidyl transfer reactions to synthesize 2,5-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication.This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2-specific nucleotidyl transfer reactions to synthesize 2,5-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described. |
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Immunohistochemistry of formalin-fixed, paraffin-embedded human Small intestine tissue. Antibody concentration 5 ug/ml. |
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WB Suggested Anti-OAS1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: Transfected 293T |
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Host: Rabbit Target Name: OAS1 Sample Tissue: Human Hela Antibody Dilution: 1.0ug/ml |
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Host: Rabbit Target: OAS1 Positive control (+): HepG2 (HG) Negative control (-): 293T (2T) Antibody concentration: 1ug/ml |
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25 ug of the indicated Human whole cell or tissue extracts was loaded onto a 12% SDS-PAGE gel. 3 ug/mL of the antibody was used in this experiment. Peptide is present in isoforms of 47, 46, 42 and 41 kDa. |
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Host: Rabbit Target Name: OAS1 Sample Tissue: Human Hela Whole Cell Antibody Dilution: 3ug/ml |
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Host: Rabbit Target Name: OAS1 Sample Tissue: Human MCF7 Whole Cell Antibody Dilution: 3ug/ml |
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Surface Plasmon Resonance Kinetic Characterization of Polyclonal Antibody Affinity. Purified polyclonal antibodies were immobilized on a Protein A/G coated Carterra LSA sensor chip (PAGH200M) at concentrations of 5, and 50 ug/mL in duplicate. Antibodies on the surface were exposed to interaction with peptides sequentially via microfluidic controlled flow at 333nM peptide concentration for kinetic characterization of the binders for affinity and specificity, followed by curve fitting using the Kinetics software. Kd determinations for both concentrations were averaged and results and standard deviation are shown. |
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OAS1 antibody - middle region (ARP51359_P050) in Transfected 293T using Western Blot |
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