PDX1 Antibody / Pancreas/duodenum homeobox protein 1, Rabbit, Polyclonal
Biozol Catalog Number:
NSJ-F52924-0.08ML
Supplier Catalog Number:
F52924-0.08ML
Alternative Catalog Number:
NSJ-F52924-0.08ML
Manufacturer:
NSJ Bioreagents
Host:
Rabbit
Category:
Antikörper
Application:
ELISA, WB
Species Reactivity:
Mouse, Rat
Immunogen:
This PDX1 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 21-55 amino acids from the N-terminal region of human Pancreas/duodenum homeobox protein 1.
Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer, the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5-[CT]TAAT[TG]-3. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.
