Upon stimulation with IFN - gamma, the expression of the three catalytic beta subunits beta1, beta2, and beta5 with iso-forms beta1i (LMP2), beta2i (MECL - 1), and beta5i (LMP7) are induced, respectively. These subunits are incorporated into the 20S proteasome to form the immune 20S proteasome. It was reported that the immunoproteasome has altered proteolytic activities compared to its normal form, which favor the generation of immunopeptides for antigen presentation.
Molecular Weight:
~700 kDa
Buffer:
20 mM Tris, 20 mM NaCl, I mM EDTA, 5 mM betaME, 10% Glycerol
Source:
Bovine red blood cells
* VAT and and shipping costs not included. Errors and price changes excepted
