FH, NT (FH, Fumarate hydratase, mitochondrial), Rabbit

Product Overview

• Article Name: FH, NT (FH, Fumarate hydratase, mitochondrial), Rabbit
• Biozol Catalog Number: USB-035648
• Supplier Catalog Number: 035648
• Alternative Catalog Number: USB-035648-200
• Manufacturer: US Biological
• Host: Rabbit
• Category: Antikörper
• Application: ELISA, WB
• Immunogen: FH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 106-135 amino acids from the N-terminal region of human FH.

Product Description

The protein encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy. Applications: Suitable for use in Western Blot, ELISA Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:100-500 Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Product Properties

• NCBI: 000134
• UniProt: P07954
• Purity: Purified by Protein A affinity chromatography.
• Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.