Monoclonal Antibody to Human PD-L1 (Clone: ABM4E54), Clone: [ABM4E54], Mouse
Artikelnummer:
ABI-10-7562
Hersteller Artikelnummer:
10-7562
Alternativnummer:
ABI-10-7562-100UG
Hersteller:
Abeomics
Wirt:
Mouse
Kategorie:
Antikörper
Applikation:
FACS, IHC, WB
Spezies Reaktivität:
Human
Immunogen:
A partial length recombinant PDL1 protein (amino acids 18-227) was used as the immunogen for this antibody.
Alternative Synonym:
CD274||B7H1||PDCD1L1||PDCD1LG1||PDL1
PD-L1 (CD274/B7-H1) is a critical membrane-bound costimulatory molecule belonging to the B7 superfamily that inhibits immune responses through its receptor, PD-1. PD-L1 plays a key role in the pathogenesis of inflammatory diseases (programmed death 1). It is widely expressed in the mononuclear phagocyte system (MPS), may co-stimulate T cells, and regulates inflammatory responses. PD-L1 exerts inflammation regulatory functions via a negative co-stimulatory effect on T cell functions to inhibit cytokine secretion, facilitate apoptosis of activated T cells and induce T cell anergy. Aberrant expression and dysregulation of CD274/PD-L1 have been reported during bacterial infection, inflammation, and in numerous autoimmune diseases.
Western blot analysis: 2-4 µg/ml, Immunohistochemical analysis-5-10 µg/ml, FACS: 1-2 µg/ml
Figure-2: Immunohistochemical analysis of PD-L1 in Hodgkins Lymphoma tissue using PD-L1 antibody (Clone: ABM4E54) at 5 µg/ml..
Figure-4: Western blot analysis of PD-L1. Anti-PD-L1 antibody (Clone: ABM4E54) was tested at 2 µg/ml on (1) A549, (2) MCF-7, (3) 293, (4) HCT-116, (5) Saos2 and (6) Hela lysates.
Figure-5: Immunohistochemical analysis of PD-L1 in Human Tonsil tissue using PD-L1 antibody (Clone: ABM4E54) at 5 µg/ml.
Figure-6: Western blot analysis of PD-L1. Anti-PD-L1 antibody (Clone: ABM4E54) was tested at 0.5 µg/ml on (1) HepG2, (2) SKBR3, (3) A431, (4) THP1, (5) NCCIT, (6) PC3, (7) PANC-1, (8) U87 and (9) KATO-111 lysates.
Figure-7: Immunohistochemical analysis of PD-L1 in Human Lung Cancer tissue using PD-L1 antibody (Clone: ABM4E54).
Figure-8: Western blot analysis of PD-L1. Anti-PD-L1 antibody (Clone: ABM4E54) was tested at 2 µg/ml on h Spleen lysate.
Figure-1: Cell Surface FLOW analysis of PD-L1 in PHA treated human PBMC using 1 µg of PD-L1 antibody (Clone: ABM4E54). Green represents isotype control, red represents anti-PD-L1 antibody. Goat anti-mouse PE conjugate was used as secondary antibody.
Figure-3: Western blot analysis of PD-L1. Anti-PD-L1 antibody (Clone: ABM4E54) was tested at 0.5 µg/ml on Recombinat lysates.
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