Ketoconazole (base), CAS [[65277-42-1]]

Product Overview

• Article Name: Ketoconazole (base), CAS [[65277-42-1]]
• Biozol Catalog Number: FBM-10-1015
• Supplier Catalog Number: 10-1015
• Alternative Catalog Number: FBM-10-1015-100MG, FBM-10-1015-500MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: ()-1-[4-(4-{[-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethan-1-one

Product Description

Cytochrome P450 inhibitor

Product Properties

• Molecular Weight: 531.43
• Purity: >98% by TLC
• Form: Off-white solid
• CAS Number: [65277-42-1]
• Formula: C26H28Cl2N4O4

Application Notes

• Application Notes: Ketoconazole is a broad spectrum antifungal agent which acts via inhibition of a cytochrome P450, CYP51A1 which is a lanosterol 14-demethylase.1 Also inhibits CYP3A and CYP1A1.2 Inhibits adrenal steroidogenesis.3 Downregulates cholesterol synthesis in drug-tolerant human lung cancer cell lines.4 Blocks the biosynthesis of leukotrienes (LT) via inhibition of 5-lipoxygenase and dose dependently inhibits LT-mediated bronchoconstriction in guinea pigs.5