Chemical Name: 2-Chloro-N-(4-chloro-3-(pyridine-2-yl)phenyl)-4-(methylsulfonyl)benzamide. Alternate Names: GDC-0449
Sonic Hedgehog signaling pathway inhibitor
Molekulargewicht:
421.30
Reinheit:
99% by TLC and HPLC NMR (Conforms)
Formulierung:
Off-white or beige solid
CAS Nummer:
[879085-55-9]
Formel:
C19H14Cl2N2O3S
Anwendungsbeschreibung:
A potent and selective Hedgehog (Hh) pathway signaling inhibitor antagonizing SMO with a Ki of 1.3 nM).1 Alters intracellular Ca2+ homeostasis and inhibits growth of cisplatin-resistant lung cancer cells.2 Inhibits two ABC transporters, ABCG2/BCRP and ABCB1/Pgp, IC50s=1.4 and 3.0 µM respectively.3 Clinically useful for the treatment of basal cell carcinoma.4 Inhibits proliferation and induces apoptosis in colon cancer cell lines.
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