Journal Club

In unserem Journal Club stellen wir Ihnen regelmäßig aktuelle Publikationen mit relevanten Methoden und Produkten vor.


18.10.2019

Different immune response of dendritic cells of newborns of allergic and healthy mothers to bacterial stimuli

Folia microbiologica, 2019

Tregs are in the center of research interest for many reasons resulting from their both physiological and pathological roles. Their main function is to suppress inadequate immune responses either to autoantigens or relatively innocuous environmental antigens such as pollen, dust, mites, antigens present in food or compounds of our microbiota. You can easily imagine a broad spectra of diseases related to impaired function of Tregs.

On the other hand, increased number and function of Tregs may be linked to certain disorders (e.g. tumor, autoimmune diseases) or insufficient anti-infectious immunity. In the case of anti-infectious immunity, pathogens (e.g. viruses) are able to induce Tregs limiting host immune responses against pathogens. Therefore, Tregs could serve as a double edged sword ...Read More


16.10.2019

Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration

Nature Neuroscience 22, (2019)

 

Efforts to reduce the personal and societal burden of neurodegenerative disease (ND) hinge on the identification of the underlying molecular mechanism(s) that causes neuronal death. One common aspect of neuronal death in Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), and Huntington’s disease (HD) is the relationship to the buildup of neurotoxic proteins. Glial cells, normally neuroprotective, can be transformed into a neuroinflammatory state (“A1” for astrocytes) stimulated by this neuronal detritus and by microglial activation. Interestingly, pathological mitochondrial fission mediated by Drp1-Fis1 interaction (as opposed to physiological fission through Drp1-Mff) is also a characteristic ...Read more

 


15.10.2019

Structural determination of the large photosystem II–light-harvesting complex II supercomplex of Chlamydomonas reinhardtii using nonionic amphipol

The Journal of Biological Chemistry 294, 2019

Recently, the application of NAPol for the cryo-EM structure determination of membrane proteins was demonstrated and the Minagawa Lab published the structure of the large photosystem II-light harvesting complex II supercomplex of Chlamydomonas reinhardtii in August, 2019. A NAPol-based purification method was able to yield the largest photosynthetic supercomplex to the highest percentage of intact configuration reported to date!

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09.10.2019

Expansion and differentiation of hepatocyte-derived liver progenitor-like cells

Nature Cell Research, 2019

Stem cells are a better model of human disease and drug reactions than animal models. Fu et al. showed that human hepatocytes could be efficiently converted to progenitor-like cells by culturing in TEM, supplemented with small molecules that enable direct reprogramming. Some of those were contributed by our partner TargetMol.

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01.10.2019

CD8+ T cells induce cachexia during chronic viral infection

Nature Immunology, May 2019

Cachexia is a major cause of morbidity and mortality for various cancers, chronic inflammation, and infections. In this study, the authors used the chronic viral infection mice model to elucidate the inflammatory drivers of IAC. The free thyroxine levels of both infected and uninfected mice were measured by an ELISA kit from CUSABIO.

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01.10.2019

Saporin-conjugated tetramers identify efficacious anti-HIV CD8+ T-cell specificities

PLOS ONE, Oct 2017

The most common use of MHC tetramers is for detection of antigen-specific T cells. Ellen M. Leitman et al. describe the use of tetramers coupled to a Saporin to selectively kill antigen-specific T cells. These tetramers have the potential to be used in immunotherapy and vaccine development.

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