ProFoldin

Drug Discovery, Drug Delivery, Biochemical Assays, and Membrane Protein Sciences

ProFoldin provides innovative and unique research tools for life sciences and drug discovery, focusing on the following fields: drug target enzyme assays, concentration measurement of various molecules and ions, liposome and nanodisc products, protein folding, extraction and reconstitution tools, molecular binding and separation products. The assays are suitable for high throughput screening (HTS). ProFoldin also offers assay services, including custom assay development, enzyme activity tests, screening of compound libraries, and IC50 measurements.

Featured Products: 

Topoisomerases - Important Targets for Cancer Chemotherapy

Topoisomerases are nuclear enzymes that play essential roles in DNA replication, transcription, chromosome segregation, and recombination. These enzymes are altering the topological state of DNA; they are capable of relaxing supercoiled DNA and of decatenating interlocked DNA.

ProFoldin offers a great selection of high-throughput assays for all topoisomerase functions, including DNA relaxation, DNA supercoiling, DNA decatenation, and ATP hydrolysis.

• For topoisomerase characterization, drug testing, and high-throughput screening (HTS) of topoisomerase inhibitors
• Fluorescence-based assays in 96-well or 384-well plate format
• General topoisomerase assays and assays for human and bacterial topoisomerases
• Gel-based DNA supercoiling, DNA relaxation, and DNA decatenation assays for visualizing the DNA topoisomerase products on agarose gels
• Also available: Topoisomerase enzymes and DNA substrates

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