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Reliance Biosciences

LipoMin™ extracellular vesicle (EV) purification

Reliance Biosciences specializes in extracellular vesicle (EV) isolation and biomarker development for the early detection of cancer and neurodegenerative diseases using plasma- or serum-derived EVs. Their proprietary LipoMin™ reagent enables highly efficient EV purification from size-exclusion chromatography (SEC) or ultracentrifugation (UC)-processed samples. By leveraging functionalized magnetic beads, LipoMin™ removes the majority of residual lipoprotein particles in just 10 minutes, significantly improving EV purity.

 

A recent ACS publication (PMID: 39149774) demonstrated LipoMin’s effectiveness:

  • For SEC-purified EV fractions, LipoMin™ eliminated 98.2% of ApoB while retaining 93.0% of EVs.
  • For resuspended UC pellets, LipoMin™ removed 76.5% of ApoA1 while preserving 90.7% of EVs.

 

With its rapid and efficient purification capabilities, LipoMin™ enhances the reliability of EV-based biomarker studies, advancing research in liquid biopsy and precision diagnostics.