Catalog Number: BOT-BNC041484-100

DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/1484), CF405S conjugate, 0.1mg/mL, Clone: [DG1/1484], Mouse, Monoclonal

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Expression of DOG-1 protein is elevated in gastrointestinal stromal tumors (GISTs), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GISTs, including all c-kit negative GISTs. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GISTs is nearly identical: 94.4% vs. 94.7%.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

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Article Name:	DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/1484), CF405S conjugate, 0.1mg/mL, Clone: [DG1/1484], Mouse, Monoclonal
BIOZOL Catalog Number:	BOT-BNC041484-100
Supplier Catalog Number:	BNC041484-100
Alternative Catalog Number:	BOT-BNC041484-100-100UL
Manufacturer:	Biotium
Host:	Mouse
Category:	Antikörper
Application:	IHC
Species Reactivity:	Human
Immunogen:	Recombinant human DOG-1 protein fragment (aa 2-101) (exact sequence is proprietary)
Conjugation:	CF405S
Alternative Names:	Anoctamin 1, Calcium Activated Chloride Channel, Discovered On Gastrointestinal Stromal Tumors Protein 1, TAOS2, ORAOV2, TMEM16A

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