Product Description
The PC-61.5.3 monoclonal antibody reacts with mouse IL-2Ralpha also known as CD25, Ly-43, p55, or Tac. IL-2Ralpha is the 55 kDa ligand-binding subunit of the interleukin 2 receptor alpha chain. IL-2Ralpha is expressed on activated mature T and B lymphocytes, thymocyte subsets, pre-B cells, and T regulatory cells. IL-2Ralpha has been shown to play roles in lymphocyte differentiation, activation, and proliferation. Alone, the IL-2Ralpha binds IL-2 with relatively low affinity however, when IL-2Ralpha associates with IL-2Rbeta (CD122) and the common gamma chain (CD132) the complex binds IL-2 with high affinity. The PC-61.5.3 antibody has been shown to inhibit the binding of IL-2 to both the low and high affinity IL-2 receptor forms. Additionally, the PC-61.5.3 antibody is commonly used to deplete CD4+FoxP3+ T regulatory cells in vivo.
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