InVivoMAb anti-mouse CD40, IgG2a, Clone: [FGK4.5/FGK45], Rat, Monoclonal
Catalog Number:
BXC-BE0016-2-INDUSTRIAL
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| Article Name: | InVivoMAb anti-mouse CD40, IgG2a, Clone: [FGK4.5/FGK45], Rat, Monoclonal |
| Biozol Catalog Number: | BXC-BE0016-2-INDUSTRIAL |
| Supplier Catalog Number: | BE0016-2 |
| Alternative Catalog Number: | BXC-BE0016-2-1MG,BXC-BE0016-2-5MG,BXC-BE0016-2-25MG,BXC-BE0016-2-50MG,BXC-BE0016-2-100MG |
| Manufacturer: | Bio X Cell |
| Host: | Rat |
| Category: | Antikörper |
| Species Reactivity: | Mouse |
| Immunogen: | Recombinant mouse CD40 fusion protein |
| The FGK4.5 monoclonal antibody reacts with mouse CD40 also known as Bp50. CD40 is a 48 kDa type I transmembrane glycoprotein that belongs to the tumor necrosis factor receptor (TNFR) superfamily. CD40 is expressed broadly on antigen-presenting cells (APCs) such as dendritic cells, B cells, macrophages, and monocytes as well as non-immune endothelial cells, basal epithelial cells, and a range of tumors. Upon binding to its ligand CD154, CD40 acts as a costimulatory molecule for the activation of B cells, dendritic cells, monocytes, and other APCs. CD40 plays roles in B cell activation, differentiation, proliferation and Ig isotype switching as well as dendritic cell maturation. Agonistic CD40 monoclonal antibodies have been shown to activate APCs and promote anti-tumor T cell responses. The FGK4.5 antibody is an agonistic antibody that has been shown to activate CD40 expressing APCs. FGK4.5 can also be used to inhibit CD40/CD154 interaction in vitro and in vivo. |
| Clonality: | Monoclonal |
| Concentration: | Lot specific,typically between 4-11 mg/ml |
| Clone Designation: | [FGK4.5/FGK45] |
| Molecular Weight: | 150 kDa |
| Isotype: | IgG2a |
| Pubmed: | 25274307 |
| Buffer: | PBS, pH 7.0, Contains no stabilizers or preservatives |
| Purity: | 95% , Determined by SDS-PAGE |
| Form: | Liquid |
| Formula: | PBS, pH 7.0, Contains no stabilizers or preservatives |
| Target: | CD40 |
| Application Notes: | in vivo CD40 activation, in vitro B cell stimulation/activation |
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