InVivoMAb anti-human CD47, Clone: [B6.H12], Mouse, Monoclonal
Catalog Number:
BXC-BE0019-1-INDUSTRIAL
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| Article Name: | InVivoMAb anti-human CD47, Clone: [B6.H12], Mouse, Monoclonal |
| Biozol Catalog Number: | BXC-BE0019-1-INDUSTRIAL |
| Supplier Catalog Number: | BE0019-1 |
| Alternative Catalog Number: | BXC-BE0019-1-1MG,BXC-BE0019-1-5MG,BXC-BE0019-1-25MG,BXC-BE0019-1-50MG,BXC-BE0019-1-100MG |
| Manufacturer: | Bio X Cell |
| Host: | Mouse |
| Category: | Antikörper |
| Species Reactivity: | Human |
| Immunogen: | Intact CD47 purified from placenta |
| The B6H12 monoclonal antibody reacts with human CD47 otherwise known as integrin-associated protein (IAP), and neurophilin. CD47 is an approximately 50 kDa glycosylated five transmembrane protein that is ubiquitously expressed by both hematopoietic cells such as T and B lymphocytes, monocytes, platelets and erythrocytes and non-hematopoietic cells. CD47 is involved in a range of cellular processes, including apoptosis, proliferation, adhesion, and migration. Furthermore, it plays a key role in immune and angiogenic responses. CD47 is a receptor for thrombospondin-1 (TSP-1), a secreted glycoprotein that plays a role in vascular development and angiogenesis. CD47 Is has been found to be overexpressed in many different tumor cells. Because of this, anti-CD47 monoclonal antibodies have been proposed and studied as a therapeutic treatment for human cancers. The B6H12 antibody has been shown to neutralize CD47 and inhibit the growth of hepatocellular carcinoma cells in vitro. |
| Clonality: | Monoclonal |
| Concentration: | Lot specific,typically between 4-11 mg/ml |
| Clone Designation: | [B6.H12] |
| Molecular Weight: | 150 kDa |
| Pubmed: | 28514441 |
| Buffer: | PBS, pH 7.0, Contains no stabilizers or preservatives |
| Purity: | 95% , Determined by SDS-PAGE |
| Form: | Liquid |
| Formula: | PBS, pH 7.0, Contains no stabilizers or preservatives |
| Target: | CD47 |
| Application Notes: | in vitro CD47 neutralization, in vivo CD47 neutralization in human tumor xenograft models or humanized mice, Flow cytometry |
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