Catalog Number: BXC-BE0028-INDUSTRIAL

InVivoMAb anti-mouse ICOSL (CD275), Clone: [HK5.3], Rat, Monoclonal

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The HK5.3 monoclonal antibody reacts with mouse ICOSL (inducible T cell co-stimulator ligand) also known as CD275, B7RP-1, and B7-H2. ICOSL is a 40 kDa immune checkpoint protein belonging to the Ig receptor superfamily. Upon ICOSL binding, ICOS signaling co-stimulates T and B cell responses. The ligand Is expressed on antigen presenting cells including splenic B cells, dendritic cells, and macrophages. ICOS signaling is also thought to be important for maintaining regulatory T cell homeostasis. The HK5.3 antibody has been shown to block the binding of ICOSL to ICOS both in vitroand in vivo. HK5.3 treatment of mice has been reported to lead to a loss of regulatory T cells.

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Article Name:	InVivoMAb anti-mouse ICOSL (CD275), Clone: [HK5.3], Rat, Monoclonal
BIOZOL Catalog Number:	BXC-BE0028-INDUSTRIAL
Supplier Catalog Number:	BE0028
Alternative Catalog Number:	BXC-BE0028-1MG,BXC-BE0028-5MG,BXC-BE0028-25MG,BXC-BE0028-50MG,BXC-BE0028-100MG
Manufacturer:	Bio X Cell
Host:	Rat
Category:	Antikörper
Species Reactivity:	Mouse
Immunogen:	Mouse B7-RP1 transfected cell line

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