Product Description
The R4-6A2 monoclonal antibody reacts with mouse IFNgamma (interferon gamma) a 20 kDa soluble pleiotropic cytokine and the sole member of the type II class of interferons. IFNgamma is primarily produced by activated lymphocytes including T, B, NK cells, and ILCs. IFNgamma exerts immunoregulatory, anti-proliferative, anti-viral, and proinflammatory activities and plays an important role in activation, growth, and differentiation of T and B lymphocytes, macrophages, NK cells and other non-hematopoietic cell types. Additionally, IFNgamma induces the production of cytokines, Fc receptor, and adhesion molecules and up-regulates MHC class I and II antigen expression by antigen presenting cells during an immune response. IFNgamma has also been shown to modulate macrophage effector functions, influence isotype switching and induce the secretion of immunoglobulins by B cells. IFNgamma signals through the IFN gamma receptor which exists as a heterodimer composed of CD119 (IFNgamma receptor 1) and AF-1 (IFNgamma receptor 2). The IFNgamma receptor is expressed ubiquitously on almost all cell types with the exception of mature erythrocytes. The R4-6A2 antibody has been shown to neutralize both natural and recombinant IFNgamma.
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