Product Description
The 53-5.8 monoclonal antibody reacts with mouse CD8beta also known as Lyt 3.2. The CD8 antigen is a transmembrane glycoprotein that acts as a co-receptor for the T cell receptor (TCR). Like the TCR, CD8 binds to class I MHC molecules displayed by antigen presenting cells (APC). CD8 is primarily expressed on the surface of cytotoxic T cells, but can also be found on thymocytes, natural killer cells, and some dendritic cell subsets. CD8 most commonly exists as a heterodimer composed of one CD8alpha and one CD8beta chain however, it can also exist as a homodimer composed of two CD8alpha chains. Both the CD8alpha and CD8beta chains share significant homology to immunoglobulin variable light chains. The molecular weight of each CD8 chain is approximately 34 kDa. The 53-5.8 antibody has been shown to deplete CD8+ T cells completely but not deplete CD8+ CD11c+ dendritic cells when used in vivo.
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