Catalog Number: BXC-BE0239-INDUSTRIAL

InVivoMAb anti-mouse 4-1BB (CD137), IgG2a, Clone: [3H3], Rat, Monoclonal

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The 3H3 monoclonal antibody reacts with mouse 4-1BB, a TNF receptor superfamily member also known as CD137. 4-1BB is a 39 kDa transmembrane protein expressed by T lymphocytes, NK cells, dendritic cells, granulocytes, and mast cells. Upon binding its ligand 4-1BBL, 4-1BB provides costimulatory signals to both CD4 and CD8 T cells through the activation of NF-kappaB, c-Jun and p38 downstream pathways. The importance of the 4-1BB pathway has been underscored in a number of diseases, including cancer. Agonistic anti-4-1BB antibodies have been reported to induce T cell mediated antitumor immunity. The 3H3 antibody is an agonistic antibody that has been shown to stimulate 4-1BB signaling in vivo.

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Article Name:	InVivoMAb anti-mouse 4-1BB (CD137), IgG2a, Clone: [3H3], Rat, Monoclonal
BIOZOL Catalog Number:	BXC-BE0239-INDUSTRIAL
Supplier Catalog Number:	BE0239
Alternative Catalog Number:	BXC-BE0239-1MG,BXC-BE0239-5MG,BXC-BE0239-25MG,BXC-BE0239-50MG,BXC-BE0239-100MG
Manufacturer:	Bio X Cell
Host:	Rat
Category:	Antikörper
Species Reactivity:	Mouse
Immunogen:	Mouse CD137 human Fc fusion protein

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