Product Description
The E60 monoclonal antibody reacts with West Nile virus (WNV) and dengue virus (DENV) envelope (E) protein. WNV and DENV are small, enveloped, single-stranded RNA viruses of the family Flaviviridae. The viral envelope of flaviviruses consists of multiple copies of the 50-60 kDa E protein and the 8 kDa M (membrane) protein. X-ray crystallography studies have revealed that the ectodomain of each E protein is comprised of three structural domains: DI, DII and DIII, connected by flexible hinges. The tip of the DII domain contains a conserved region termed the ''fusion loop, which is required for membrane fusion of the viral envelope with the host cell membrane. The E60 antibody is a flavivirus cross-reactive neutralizing antibody that binds to an epitope in the fusion loop peptide of domain II on the E protein.
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