Product Description
The GG8 monoclonal antibody reacts with human VISTA (V-type immunoglobulin domain-containing suppressor of T cell activation), which is a negative checkpoint regulator (NCR) from the B7 family. Several in vitro and in vivo studies have demonstrated that the VISTA protein acts as a ligand as well as a receptor. VISTA is mainly expressed by myeloid cells and T cells, and in the CNS, VISTA is also expressed by microglial and endothelial cells. Unlike other NCR proteins, VISTA is expressed on naive T cells, wherein its expression is negatively regulated by T cell activation. Besides its role in regulation of T cell quiescence (i.e., the suppression of T cells), VISTA is involved in efferocytosis, cytokine production (IL-10, IFN-gamma, and TNF-alpha), and chemotaxis in myeloid cells.
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