Product Description
The XMG1.2 monoclonal antibody reacts with mouse IFNgamma (interferon gamma) a 20 kDa soluble pleiotropic cytokine and the sole member of the type II class of interferons. IFNgamma is primarily produced by activated lymphocytes including T, B, NK cells, and ILCs. IFNgamma exerts immunoregulatory, anti-proliferative, anti-viral, and proinflammatory activities and plays an important role in activation, growth, and differentiation of T and B lymphocytes, macrophages, NK cells and other non-hematopoietic cell types. Additionally, IFNgamma induces the production of cytokines, Fc receptor, and adhesion molecules and up-regulates MHC class I and II antigen expression by antigen presenting cells during an immune response. IFNgamma has also been shown to modulate macrophage effector functions, influence isotype switching and induce the secretion of immunoglobulins by B cells. IFNgamma signals through the IFN gamma receptor which exists as a heterodimer composed of CD119 (IFN gamma receptor 1) and AF-1 (IFN gamma receptor 2). The IFNgamma receptor is expressed ubiquitously on almost all cell types with the exception of mature erythrocytes. The XMG1.2 antibody is a neutralizing antibody. Bio X Cell is pleased to offer XMG1.2-CP058. XMG1.2-CP058 is a recombinant, chimeric version of the original XMG1.2 with identical variable domain sequences and constant region sequences converted from Rat IgG1, kappa to mouse IgG1, kappa for use in murine models. Species-matched chimeric antibodies exhibit regulated effector functions-including Fc receptor binding and complement activation-and cause less immunogenicity and formation of anti-drug antibodies (ADAs) than xenogenic antibodies in animal models. The highly controlled sequence and lack of genetic drift in recombinant antibodies provide more reliable and reproducible results over hybridoma derived antibodies.
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