Product Description
The TM-beta 1 monoclonal antibody reacts with mouse CD122 also known as the IL-2 receptor beta chain. CD122 is a 70-75 kDa subunit of the IL-2 receptor and the IL-15 receptor. CD122 is expressed on NK cells and at lower levels by T lymphocytes, B lymphocytes, monocytes, and macrophages. The IL-2R has been shown to play roles in lymphocyte differentiation, activation, and proliferation. In complex with IL-2Ralpha, IL-2R binds IL-2 with relatively low affinity however, when CD122 combines with IL-2Ralpha and the common gamma chain (CD132) the complex binds IL-2 with high affinity. The TM-beta 1 antibody is reported to inhibit binding of IL-2 to the IL-2R. Additionally, this antibody has been shown to deplete CD122 expressing NK cells with administered in vivo.
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