Product Description
The LOB12.3-CP038 monoclonal antibody is a chimeric version of the original LOB12.3 antibody. The variable domain sequences are identical to the original LOB12.3 but the constant region sequences have been switched from rat IgG1 to mouse IgG2a. The LOB12.3-CP038 antibody also contains a LALA-PG mutation in the Fc fragment rendering it unable to bind to endogenous Fcgamma receptors. The LOB12.3-CP038 antibody reacts with mouse 4-1BB, a TNF receptor superfamily member also known as CD137. 4-1BB is a 39 kDa transmembrane protein expressed by T lymphocytes, NK cells, dendritic cells, granulocytes, and mast cells. Upon binding its ligand 4-1BBL, 4-1BB provides costimulatory signals to both CD4 and CD8 T cells through the activation of NF- kappaB, c-Jun and p38 downstream pathways. The importance of the 4-1BB pathway has been underscored in a number of diseases, including cancer. Agonistic anti-4-1BB antibodies have been reported to induce T cell mediated antitumor immunity. The LOB12.3 antibody is an agonistic antibody that has been shown to stimulate 4-1BB signaling and delay tumor growth in vivo when administered in combination with immune checkpoint inhibitors.
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