Product Description
The RB6-8C5-CP135 monoclonal antibody is a chimeric version of the original RB6-8C5 antibody. The variable domain sequences are identical to the original RB6-8C5 but the constant region sequences have been switched from rat IgG2b to mouse IgG2a. The RB6-8C5-CP135 antibody contains no Fc mutations just as the original rat IgG2b antibody does not. The RB6-8C5-CP135 monoclonal antibody reacts strongly with mouse Ly6G and weakly with mouse Ly6C previously referred to as GR-1. Ly6G is a 21-25 kDa member of the Ly-6 superfamily of GPI-anchored cell surface proteins with roles in cell signaling and cell adhesion. Ly6G is expressed differentially during development by cells in the myeloid lineage including monocytes macrophages granulocytes and neutrophils. Monocytes typically express Ly6G transiently during development while mature granulocytes and peripheral neutrophils retain expression making Ly6G a good cell surface marker for these populations.The RB6-8C5 antibody has been shown to inhibit the binding of the 1A8 antibody. The 1A8 monoclonal antibody reacts specifically with mouse Ly6G with no reported cross reactivity with Ly6C.
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