Product Description
CPB530 is a 1+1 bivalent bispecific designed to simultaneously target mouse TL1A (TNFSF15) and mouse IL23p19. This bispecific was designed to bind and inhibit two independent, yet convergent, pathogenic drivers of the inflammatory environment. Blocking TL1A prevents the amplification of T-cell responses and inhibits the production of pro-inflammatory cytokines such as IFN-gamma and IL-17. Inhibiting the p19 subunit of IL-23 prevents the activation of the IL-23 receptor (IL-23R) and subsequent downstream signaling that drives the expansion and survival of pathogenic T cells. By preventing the synergistic activation of T cells by both IL-23 and TL1A, bispecific antibodies effectively dampen the inflammatory cascade and help restore immune homeostasis in affected tissues.
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