Human TIGIT Protein, Fc Tag (MALS verified), Unconjugated

Produktübersicht

• Artikelname: Human TIGIT Protein, Fc Tag (MALS verified), Unconjugated
• Artikelnummer: ABS-TIT-H5254-1MG
• Hersteller Artikelnummer: TIT-H5254-1mg
• Alternativnummer: ABS-TIT-H5254-1MG
• Hersteller: AcroBiosystems
• Wirt: Human
• Kategorie: Proteine/Peptide
• Spezies Reaktivität: Human
• Konjugation: Unconjugated

Produktbeschreibung

Tcell immunoreceptor with Ig and ITIM domains (TIGIT) is also known as Vset and immunoglobulin domaincontaining protein 9 (VSIG9), Vset and transmembrane domaincontaining protein 3 (VSTM3),which belongs to singlepass type I membrane protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosinebased inhibitory motif (ITIM). TIGIT is expressed at low levels on peripheral memory and regulatory CD4+ Tcells and NK cells and is upregulated following activation of these cells (at protein level). TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses Tcell activation by promoting the generation of mature immunoregulatory dendritic cells. - Proteine/Peptide

Produkteigenschaften

• Molekulargewicht: 39.7 kDa
• Tag: C-Fc
• NCBI: 495
• Puffer: PBS, pH7.4
• Reinheit: 95%
• Formulierung: Powder
• Target-Kategorie: TIGIT

Bilder

Immobilized Human CD155, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. CD5-H5254) at 5 µg/mL (100 µL/well) can bind Human TIGIT, Fc Tag (Cat. No. TIT-H5254) with a linear range of 0.6-10 ng/mL (QC tested).

Serial dilutions of Human TIGIT Neutralizing antibody were added into Human TIGIT, Fc Tag (Cat. No. TIT-H5254): Biotinylated Human CD155, Fc,Avitag (Cat. No. CD5-H82F6) binding reactions. The half maximal inhibitory concentration (IC50) is 0.55834 µg/mL (Routinely tested).

TIT-H5254-1mg

Human TIGIT, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.