Anti-PD-L1 from Rabbit (HL1041) - unconj., IgG, Unconjugated, Monoclonal

Catalog Number: DNA-IHC-184010
Article Name: Anti-PD-L1 from Rabbit (HL1041) - unconj., IgG, Unconjugated, Monoclonal
Biozol Catalog Number: DNA-IHC-184010
Supplier Catalog Number: IHC-184010
Alternative Catalog Number: DNA-IHC-184010
Manufacturer: dianova
Host: Rabbit
Category: Antikörper
Application: IHC-P, IHC-F
Species Reactivity: Human
Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human PD-L1. The exact sequence is proprietary.
Conjugation: Unconjugated
Alternative Names: CD274 molecule , B7-H , B7H1 , PD-L1 , PDCD1L1 , PDCD1LG1 , PDL1
Anti-PD-L1 from Rabbit (HL1041) - unconj., IgG, Unconjugated, Monoclonal

This antibody is specific for PD-L1 protein, ligand of immune checkpoint receptor PD-1.

Cancer cells and the cells of the surrounding microenvironment have been shown to upregulate the expression of components to suppress the antitumor immune response by generating coinhibitory signals. PD-1 and CTLA-4 emerged as the most successful immune targets for anticancer therapies.

The PD-1/PD-L1 and CTLA-4 axis also has become a focus of SARS-CoV-2 research, as PD-L1 and CTLA-4 mediated T-cell dysfunction and exhaustion is observed in symptomatic COVID-19 patients. This PD-L1 antibody shows no cross-reaction with SARS-CoV or MERS-CoV spike proteins.

 

 

Positive Control: Placenta, Tonsil

Clonality: Monoclonal
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration.)
Clone Designation: HL1041
Molecular Weight: 33
Isotype: IgG
NCBI: 29126
UniProt: Q9NZQ7
Buffer: PBS
Purity: Affinity purified by Protein A.
Target: Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human PD-L1. The exact sequence is proprietary.
IHC of PD-L1 with anti-PD-L1 clone HL1041 (rabbit monoclonal) in FFPE HNSCC Section (human)
IHC of PD-L1 with anti-PD-L1 clone HL1041 ((rabbit monoclonal) in human tonsil (FFPE)