CAS Number: 107761-42-2 Molecular Weight: 4511.3 Salt Form: TFA Purity: >95% Sequence (3-letter): Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH Sequence (1-letter): DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA-OH Storage: -20 ?C or below Solubility: 1 mg/mL in 50 mM Tris or dissolve 1 mg in 70-80 uL 1% NH4OH then dilute to 1 mg/mL with 1X PBS. Do not store in 1% NH4OH, dilute immediately with PBS. Beta amyloid (1-42) is the predominant form of ?-amyloid protein found in the brains of patients with Alzheimer?s disease and Down?s syndrome. Beta amyloid down-regulates bcl-2 (a key anti-apoptotic protein) and upregulates bax (cell death promoter) with evidence suggesting that it renders neurons vulnerable to age-dependent stress and neurodegeneration
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