Lipid OA2

Product Overview

• Article Name: Lipid OA2
• Biozol Catalog Number: ECH-N-1002
• Supplier Catalog Number: N-1002
• Alternative Catalog Number: ECH-N-1002-100MG, ECH-N-1002-10MG, ECH-N-1002-25MG
• Manufacturer: Echelon Biosciences
• Category: Molekularbiologie

Product Description

Lipid OA2 is an ionizable lipid which can form single component lipid nanoparticles (LNPs) for delivery of RNA. Similar to lipid-based transfection reagents like LipofectamineTM, pre-formed OA2 vesicles are incubated with RNA then the mixture is directly added cells. OA2 LNPs delivered siRNA to downregulate cytokine signaling 1 (SOCS1) in mouse bone marrow dentritic cells. These SOCS downregulated DCs were used as a vaccine which reduced tumor size in a B16-OVA mouse model.