Arecoline HBr, CAS [[300-08-3]]

Product Overview

• Article Name: Arecoline HBr, CAS [[300-08-3]]
• Biozol Catalog Number: FBM-10-1016
• Supplier Catalog Number: 10-1016
• Alternative Catalog Number: FBM-10-1016-250MG, FBM-10-1016-1G
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 1,2,5,6-Tetrahydro-1-methyl-3-pyridinecarboxylic acid, methyl ester, hydrobromide

Product Description

ACAT1 inhibitor

Product Properties

• Molecular Weight: 236.11
• Purity: 98% by TLC, NMR (Conforms)
• Form: White solid
• CAS Number: [300-08-3]
• Formula: C8H13NO2 HBr

Application Notes

• Application Notes: Tyrosine407 phosphorylation activates mitochondrial acetyl-CoA acetyltransferase 1 (ACAT1) by stabilizing its tetramer. This is believed to be the mechanisms by which ACAT1 is ''hijacked and contributes to the Warburg effect in cancer. Arecoline is a covalent inhibitor of ACAT1 which binds to and disrupts only ACAT1 tetramers (IC50=11.1 µM). ACAT2 and DLAT are not inhibited. Treatment of xenograft nude mice with Arecoline resulted in a dose-dependent reduction in tumor mass.1 Agonist at muscarinic acetylcholine receptors M1 - M5 (EC50 in the range of 7-410 nM).2 May be effective in dementia.3