Chemical Name: (2E,4E,6R)-7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide. Alternate Names: TSA
HDAC inhibitor
Molecular Weight:
302.38
Purity:
99% by HPLC NMR (Conforms)
Form:
Tan solid
CAS Number:
[58880-19-6]
Formula:
C17H22N2O3
Application Notes:
Trichostatin A (58880-19-6) is a potent and selective histone deacetylase (HDAC) inhibitor (Ki = 3.4 nM). Induces reversion of ras transformed cells to normal morphology. Trichostatin A induces dedifferentiation of primordial germ cells into embryonic germ cells. Cell permeable and active in vivo. Decreased global chromatin condensation increasing gene-editing efficiency 2-4X.4 Part of the CRISPY mix for increasing precise gene editing.5
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