AM-80, CAS [[94497-51-5]]

Product Overview

• Article Name: AM-80, CAS [[94497-51-5]]
• Biozol Catalog Number: FBM-10-2534
• Supplier Catalog Number: 10-2534
• Alternative Catalog Number: FBM-10-2534-10MG,FBM-10-2534-50MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Tamibarotene, NSC608000, Retinobenzoic acid

Product Description

Selective RARa agonist

Product Properties

• Molecular Weight: 351.45
• Purity: >98% HPLC, NMR (Conforms)
• Form: White solid
• CAS Number: [94497-51-5]
• Formula: C22H25NO3

Application Notes

• Application Notes: AM80 (94497-51-5) is a retinoic acid receptor alpha (RARalpha) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells.1 Exhibits antiproliferative effects against a variety of human tumor cells lines (mean values of 35, 40 and 60% growth inhibition at 0.1, 1 and 10 µM respectively).2 It ameliorates chronic graft-versus-host disease by down-regulating Th1 and Th17.3 AM80 induces neuronal differentiation in a human neuroblastoma NH-12 cell line.4 Pulmonary administration of AM80 regenerates collapsed alveoli.5