BMS-833923, CAS [[1059734-66-5]]

Product Overview

• Article Name: BMS-833923, CAS [[1059734-66-5]]
• Biozol Catalog Number: FBM-10-3049
• Supplier Catalog Number: 10-3049
• Alternative Catalog Number: FBM-10-3049-5MG,FBM-10-3049-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: N-(2-Methyl-5-((methylamino)methyl)phenyl)-4-((4-phenylquinazolin-2-yl)amino)benzamide. Alternate Names: XL-139

Product Description

SMO antagonist

Product Properties

• Molecular Weight: 473.58
• Purity: >98% by HPLC, NMR (Conforms)
• Form: Yellow solid
• CAS Number: [1059734-66-5]
• Formula: C30H27N5O

Application Notes

• Application Notes: BMS-833923 (1059734-66-5) is a smoothened (SMO) antagonist. It decreased cell proliferation and induced apoptosis (EC50=10 mM) via the intrinsic pathway in esophageal adenocarcinoma cell lines.1 Ameloblastoma cells with an activating SMO-L412F mutation were insensitive to vismodegib (another SMO antagonist) but BMS-833923 significantly reduced downstream Hedgehog signaling and tumor cell viability.2 In developmental studies BMS-833923 has been characterized as a uniquely effective SMO inhibitor when it was used to show that Sonic hedgehog is functionally dedicated to ray branching during fin regeneration in zebrafish.3 Orally active.