PY-60, CAS [[2765218-56-0]]

Product Overview

• Article Name: PY-60, CAS [[2765218-56-0]]
• Biozol Catalog Number: FBM-10-3924
• Supplier Catalog Number: 10-3924
• Alternative Catalog Number: FBM-10-3924-5MG, FBM-10-3924-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 5-Phenyl-N-[3-(1,3-thizol-2-yl)propyl]-1,2-oxazole-3-carboxamide

Product Description

YAP Activator

Product Properties

• Molecular Weight: 313.38
• Purity: >98% by HPLC , NMR (Conforms)
• Form: White solid
• CAS Number: [2765218-56-0]
• Formula: C16H15N3O2S

Application Notes

• Application Notes: PY-60 (2765218-56-0) activates YAP transcriptional activity (EC50 = 1.6 µM) via delocalization of annexin A2 (ANXA2) from cell membranes leading to Hippo inactivation, a key controller of YAP.1 It was able to induce serum-free expansion of MCF10A cells and epidermal keratinocytes and their precursors ex vivo and in adult mice. PY-60 promoted regenerative repair of cutaneous wounds in pig and human models by enabling a pro-proliferative transcriptional program in keratinocytes and dermal cells that accelerated re-epithelization and regranulation of the wound bed.2