CPI203, CAS [[1446144-04-2]]

Product Overview

• Article Name: CPI203, CAS [[1446144-04-2]]
• Biozol Catalog Number: FBM-10-4048
• Supplier Catalog Number: 10-4048
• Alternative Catalog Number: FBM-10-4048-5MG, FBM-10-4048-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: (S)-2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6h-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetamide. Alternate Names: CPI-267203, 2-[(9S)-7-(4-Chlorophenyl)-4,5-13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetamide

Product Description

BET bromodomain inhibitor

Product Properties

• Molecular Weight: 399.90
• Purity: 98% by HPLC NMR (Conforms)
• Form: White to off-white solid
• CAS Number: [1446144-04-2]
• Formula: C19H18ClN5OS

Application Notes

• Application Notes: CPI203, a JQ1 analog, is a potent and selective inhibitor of the BET bromodomain BRD4 (IC50 = 26 nM).1 It helps promote the maintenance of hematopoietic stem cells via repression of Myc expression.2 CPI203 reversibly suppressed intestinal stem cell differentiation in a mouse model.3 It enhanced the expansion of human cord blood hematopoietic stem cells without losing cell viability.4 CPI203 displays synergistic antitumor activity with various agents including lenalidomide5, bortezomib6, and PARP inhibitors7.