XMU-MP-1, CAS [[2061980-01-4]]

Product Overview

• Article Name: XMU-MP-1, CAS [[2061980-01-4]]
• Biozol Catalog Number: FBM-10-4294
• Supplier Catalog Number: 10-4294
• Alternative Catalog Number: FBM-10-4294-5MG, FBM-10-4294-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 4-[(6,10-Dihydro-5,10-dimethyl-6-oxo-5H-pyrimido[5,4-b]thieno[3,2-e]diazepin-2-yl)amino]benzenesulfonamide

Product Description

Potent and selective MST1/2 kinase inhibitor

Product Properties

• Molecular Weight: 416.47
• Purity: >98% by HPLC, NMR (Conforms)
• Form: Yellow solid
• CAS Number: [2061980-01-4]
• Formula: C17H16N6O3S2

Application Notes

• Application Notes: XMU-MP-1 is a potent, reversible, and selective inhibitor of the HIPPO pathway kinases MST1 and MST2 (IC50s = 71 nM and 38 nM respectively).1 It promoted liver repair/regeneration in mice and attenuated acetaminophen-induced liver injury. In a subarachnoid hemorrhage mouse model, XMU-MP-1 alleviated neurological deficits, brain edema, neuroinflammation, and white matter injury.2 XMU-MP-1 was also cardioprotective in mice with transverse aortic constriction3 and against ischemia/reperfusion injury4.