K-975, CAS [[2563855-03-6]]

Product Overview

• Article Name: K-975, CAS [[2563855-03-6]]
• Biozol Catalog Number: FBM-10-4297
• Supplier Catalog Number: 10-4297
• Alternative Catalog Number: FBM-10-4297-1MG, FBM-10-4297-5MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: N-[3-(4-Chlorophenoxy)-4-methylphenyl]prop-2-enamide, N-[3-(4-Chlorophenoxy)-4-methylphenyl]acrylamide

Product Description

YAP/TAZ-TEAD signaling inhibitor

Product Properties

• Molecular Weight: 287.74
• Purity: >98% by HPLC, NMR (Conforms)
• Form: White solid
• CAS Number: [2563855-03-6]
• Formula: C16H14ClNO2

Application Notes

• Application Notes: K-975 is a covalent inhibitor of YAP/TAZ-TEAD signaling. It binds to the palmitate-binding pocket of TEAD preventing its association with YAP/TAZ.1 K-975 inhibited proliferation of NF2-non-expressing mesothelioma cell lines. K-975 promoted liver progenitor cell to hepatocyte differentiation via suppression of YAP signaling.2 It sensitized YAP-expressing RET-aberrant cancer cells to RET kinase inhibitors.3