RepSox, CAS [[446859-33-2]]

Product Overview

• Article Name: RepSox, CAS [[446859-33-2]]
• Biozol Catalog Number: FBM-10-4546
• Supplier Catalog Number: 10-4546
• Alternative Catalog Number: FBM-10-4546-5MG,FBM-10-4546-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: E-616452, SNJ 2511, 616452

Product Description

TGFbetaR-1 / ALK5 inhibitor

Product Properties

• Molecular Weight: 287.32
• Purity: 99% by HPLC, NMR (Conforms)
• Form: Pale yellow solid
• CAS Number: [446859-33-2]
• Formula: C17H13N5

Application Notes

• Application Notes: RepSox is a potent (IC50 ALK5 auto-P= 4 nM, IC50 TGF-b cellular assay = 23 nM) inhibitor of the TGF-beta type I receptor (ALK5).1 RepSox can replace Sox2 in reprogramming adult cells into pluripotent stem cells via induction of Nanog transcription.2 It was able to convert astrocytes into neuronal cells as part of a small molecule cocktail (along with valproic acid and CHIR99021).3,4