Wnt-C59, CAS [[1243243-89-1]]

Product Overview

• Article Name: Wnt-C59, CAS [[1243243-89-1]]
• Biozol Catalog Number: FBM-10-4605
• Supplier Catalog Number: 10-4605
• Alternative Catalog Number: FBM-10-4605-5MG, FBM-10-4605-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 4-(2-Methyl-4-pyridinyl)-N-[4-(3-pyridinyl)phenyl]benzeneacetamide

Product Description

Porcupine inhibitor

Product Properties

• Molecular Weight: 379.46
• Purity: >98% by HPLC NMR (Conforms)
• Form: Tan Solid
• CAS Number: [1243243-89-1]
• Formula: C25H21N3O

Application Notes

• Application Notes: Wnt-C59 is a potent (IC50 = 74 pmol/L) inhibitor of Porcupine (PORCN), a Wnt-acyltransferase. Blockage of Wnt-acyltransferase prevents secretion of all Wnt isoforms. It was able to block progression of mammary tumors in MMTV-WNT1 transgenic mice.1 Wnt-C59 strongly inhibited the growth of intestinal neoplasia in RZ-mutant mice. Wnt-C59 was able to efficiently differentiate pluripotent stem cells into cortical neurons (CTIP2+/COUP-TF1). Wnt-C59 was also able to dramatically attenuate kidney fibrosis via inhibition of collagen mRNA expression and expression of inflammatory cytokines.