Ezatiostat, CAS [[168682-53-9]]

Product Overview

• Article Name: Ezatiostat, CAS [[168682-53-9]]
• Biozol Catalog Number: FBM-10-4711
• Supplier Catalog Number: 10-4711
• Alternative Catalog Number: FBM-10-4711-5MG, FBM-10-4711-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: Ethyl (2S)-2-amino-5-[[(2R)-3-benzylsulfanyl-1-[[(1R)-2-ethoxy-2-oxo-1-phenylethyl]amino]-1-oxopropan-2-yl]amino]-5-oxopentanoate. Alternate Names: TLK199, TER199

Product Description

GSTP1 inhibitor

Product Properties

• Molecular Weight: 529.65
• Purity: 98% by HPLC, NMR (Conforms)
• Form: White solid
• CAS Number: [168682-53-9]
• Formula: C27H35N3O6S

Application Notes

• Application Notes: Ezatiostat is a peptidomimetic inhibitor of glutathione S-transferase P1-1 (GSTP1).1,2 It showed significant hematopoietic stimulatory activity possibly via JNK activation through disruption of the GSTP/JNK interaction.3 Ezatiostat displayed efficacy in treating myelodysplastic syndrome.4,5 Combined treatment with ezatiostat and a PRDX6 inhibitor displayed synergistic effects in the treatment of neuroblastoma in vitro and in vivo.6