Chroman 1, CAS [[1273579-40-0]]

Product Overview

• Article Name: Chroman 1, CAS [[1273579-40-0]]
• Biozol Catalog Number: FBM-10-4912
• Supplier Catalog Number: 10-4912
• Alternative Catalog Number: FBM-10-4912-1MG,FBM-10-4912-5MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien

Product Description

ROCK II inhibitor / Stem cell cytoprotectant

Product Properties

• Molecular Weight: 436.51
• Purity: 99% by HPLC NMR (conforms)
• Form: White solid
• CAS Number: [1273579-40-0]
• Formula: C24H28N4O4

Application Notes

• Application Notes: Extremely potent inhibitor of Rho kinase II (ROCK-II)1,2 - it displayed greater selectivity and potency compared to Y-27632 (IC50s: ROCK I = 52 pM/ROCK II = 1 pM, Y-27632 IC50s: ROCK I = 71 nM/ROCK II = 46 nM)3. Chroman 1, used in conjunction with trans-ISRIB (Cat 10-1539), Emricasan (Cat 10-4280), and polyamines (CEPT cocktail), promotes cytoprotective cell survival in human pluripotent stem cells (hPSCs) and was found to superior to Y-27632.3 Chroman 1 is an important new tool in the generation and maintenance of stem cells.