IM-12, CAS [[1129669-05-1]]

Product Overview

• Article Name: IM-12, CAS [[1129669-05-1]]
• Biozol Catalog Number: FBM-10-5125
• Supplier Catalog Number: 10-5125
• Alternative Catalog Number: FBM-10-5125-5MG, FBM-10-5125-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 3-(4-Fluorophenylethylamino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione

Product Description

GSK-3ß inhibitor

Product Properties

• Molecular Weight: 377.41
• Purity: 98% by HPLC NMR (Conforms)
• Form: Yellow solid
• CAS Number: [1129669-05-1]
• Formula: C22H20FN3O2

Application Notes

• Application Notes: A potent and selective inhibitor of glycogen synthase kinase 3 (GSK-3) IC50=53 nM which induces neuronal differentiation.1 Activates the Wnt--catenin signaling pathway and attenuates tissue plasminogen activator-induced hemorrhagic transformation after acute ischemic stroke in animal models.2 Promoted hair follicle growth in vitro and antagonized the inhibition of hair follicles by dihydrotestosterone.3 Down-regulates Sox9 expression in limbal epithelial stem/progenitor cells leading to increased differentiation.4