Chemical Name: 4-[[6-[Cyclopropylcarbonyl)amino]-4-pyrimidinyl]oxy]-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-benzeneacetamide
Stimulates pancreatic beta-cell proliferation
Molecular Weight:
568.60
Purity:
>98% by HPLC NMR (Conforms)
Form:
Off-white to beige solid
CAS Number:
[1421227-53-3]
Formula:
C29H31F3N6O3
Application Notes:
Stimulates human beta-cell proliferation both in a dispersed islet proliferation assay and in intact human cultures.1 It has been shown to induce both alpha- and beta-cell proliferation.2 May lead to the development of new therapeutics for diabetes.3 Induces adult hippocampal neurogenesis correlating with its antidepressant effect in a rat model of chronic unpredictable mild stress-induced depression.4 Has been used together with TTNPB and azakenpaullone, as a defined chemical cocktail to induce mouse totipotent stem cells.5 Cell permeable.
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