Catalog Number: GTX01555

SARS-CoV / SARS-CoV-2 (COVID-19) spike antibody [CR3022], IgG1, Unconjugated, Human, Monoclonal

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SARS-CoV / SARS-CoV-2 (COVID-19) spike antibody [CR3022] binds to both SARS-CoV and SARS-CoV-2 with high affinity (PMID: 16796401 & 32065055). The initial characterization of the binding of this antibody was performed by ELISA and indicates potential for the development of diagnostic assays, as both virus-capture assays, or as controls in serological assays measuring immune responses to virus exposure. The original human IgG1 version of the antibody works synergistically in combination with another non-competing SARS antibody CR3014 and is a potential candidate for passive immune prophylaxis of SARS-CoV infection (ter Meulen et al., 2006). The original antibody (human IgG1) was also reported to bind the SARS-CoV-2 RBD (KD of 6.3 nM). This antibody may have potential as a therapeutic agent, alone or in combination with other neutralizing antibodies for treatment of SARS-CoV-2 infections (Tian et al., 2020).

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Article Name:	SARS-CoV / SARS-CoV-2 (COVID-19) spike antibody [CR3022], IgG1, Unconjugated, Human, Monoclonal
BIOZOL Catalog Number:	GTX01555
Supplier Catalog Number:	GTX01555
Alternative Catalog Number:	GTX01555-100
Manufacturer:	GeneTex
Host:	Human
Category:	Antikörper
Application:	ELISA, NeA
Species Reactivity:	Virus
Immunogen:	The original monoclonal antibody was generated by sequencing peripheral blood lymphocytes of a patient exposed to the SARS-CoV.
Conjugation:	Unconjugated
Alternative Names:	2019-nCoV Spike, COVID-19 Spike, SARS-CoV-2 Spike, covid-19, sars-cov, sars-cov-2

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