Human ACVR1B/Activin RIB Protein (ALK-HM204)

Product Overview

• Article Name: Human ACVR1B/Activin RIB Protein (ALK-HM204)
• Biozol Catalog Number: KAB-ALK-HM204
• Supplier Catalog Number: ALK-HM204
• Alternative Catalog Number: KAB-ALK-HM204-100UG, KAB-ALK-HM204-500UG
• Manufacturer: KactusBio
• Category: Proteine/Peptide
• Species Reactivity: Human
• Alternative Names: ACVR1B, ACTR-IB, ALK 4, ALK-4, SKR2, ACVRLK4, ALK4, Activin R1B

Product Description

Recombinant Human ACVR1B/Activin RIB Protein is expressed from HEK293 with hFc (IgG1) tag at the C-terminus.It contains Ser24-Glu126.

Product Properties

• Molecular Weight: The protein has a predicted MW of 37.36 kDa. Due to glycosylation, the protein migrates to 45-55 kDa based on Bis-Tris PAGE result.
• Tag: C-hFc (IgG1)
• UniProt: P36896
• Buffer: Lyophilized from 0.22 µm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
• Expression System: HEK293
• Purity: > 95% as determined by Bis-Tris PAGE,> 95% as determined by HPLC
• Form: Lyophilized
• Sequence: Ser24-Glu126
• Target: ACVR1B/Activin RIB

Images

Human ACVR1B on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

The purity of Human ACVR1B is greater than 95% as determined by SEC-HPLC.

Human ACVR1B, hFc Tag captured on CM5 Chip via Protein A can bind Human TDGF1, His Tag-with an affinity constant of 0.16 uM as determined in SPR assay (Biacore T200).

Human ACVR1B, hFc Tag captured on CM5 Chip via Protein A can bind Human Activin A, No Tag with an affinity constant of 11.57 nM as determined in SPR assay (Biacore T200).

Loaded Human ACVR1B, hFc Tag on ProA-Biosensor can bind Human TDGF1, His Tag with an affinity constant of 0.13 µM as determined in BLI assay (Gator Prime).