Human Type I Interferon Neutralizing Antibody Mixture, Unconjugated

Product Overview

• Article Name: Human Type I Interferon Neutralizing Antibody Mixture, Unconjugated
• Biozol Catalog Number: PBL-39000-1
• Supplier Catalog Number: 39000-1
• Alternative Catalog Number: PBL-39000-1
• Manufacturer: PBL Assay Science
• Category: Antikörper
• Application: NeA
• Conjugation: Unconjugated

Product Description

Mixture of monoclonal and polyclonal antibodies directed against human Type I interferon receptor and several Type I interferons

Additional Information

Product Features: 

• Mixture of monoclonal and polyclonal antibodies directed against human Type 1 Interferons (IFNs) and Type 1 Receptor Subunit 2 (IFNAR2)
• Effectively neutralizes biological activity of human IFN-alpha, IFN-beta, IFN-omega, IFN-kappa, and IFN-epsilon
• Improves neutralization of multiple Type I IFNs often found in complex samples by employing a broadly neutralizing custom antibody cocktail
• Unconjugated

 

Fig: Representative neutralization curves of Human Type I IFN Neutralizing Antibody Mixture (Catalog No. 39000) (diluted 1:50) to human interferon alpha, beta, and omega. In this assay, A549 cells (human lung carcinoma) were incubated with the antibody mixture and titrated interferon, followed by challenging with encephalomyocarditis virus (EMCV).

 

 

Specifications

• Formulation: Supplied frozen in phosphate-buffered saline (PBS)
• Purification: A combination of Protein G affinity chromatography and other conventional chromatographical methods.
  Endotoxin level < 1 EU/μg
• Bioactivity: Encephalomyocarditis Virus (EMCV) was used to challenge A549 cells which were incubated with a constant concentration of the antibody mixture and the titrated interferon.
• Specificity: Blocks biological activity of human Type I interferons (alpha, beta, omega, kappa, epsilon)
  No cross reactivity observed with the following human interferons: gamma, lambda 1, lambda 2, lambda 3; or mouse interferons: alpha, beta, gamma
• Storage: For retention of full activity store at -70°C or below and avoid repeated freeze/thaw cycles
• Synonyms: Type I interferon, Type I IFN, Neutralizing, Neutralization, Type I Interferon Receptor, Antibody Cocktail

Product Properties

• Clonality: Polyclonal
• Buffer: Phosphate - buffered saline (PBS)
• Purity: A combination of Protein G affinity chromatography and other conventional chromatographical methods
• Form: Frozen

Images

Representative neutralization curves of Human Type I IFN Neutralizing Antibody Mixture (Catalog No. 39000) (diluted 1:50) to human interferon alpha, beta, and omega.